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Fields Medical Life Sciences Information Communication Environment Nanotechnology / Materials Energy Manufacturing Technology Social Infrastructure Frontier Liberal Arts Themes Researchers JP Top Researchers Researchers 287 Result(s), Themes 250 Result(s) A B C D E F G H I J K L M N O P Q R S T U V W X Y Z View All View Details A A B C D E F G H I J K L M N O P Q R S T U V W X Y Z View Details View All View Details  A Additive Manufacturing of Metallic Parts with Electron Beam Melting (EBM)       NEXT PREV 特徴・独自性 Electron beam melting (EBM) is a type of additive manufacturing technologies. EBM uses electron beam as an energy source to melt metal powder and produce metal thin layers. This sequence is repeated in a layer-by-layer manner to fabricate three-dimensional (3D) components. This technology can produce any kinds of structures based on 3D CAD models and is suitable for custom-made manufacturing. In addition, our recent studies revealed that the unique microstructure, such as directional solidification and uniform dispersions of fine precipitates, are obtained by EBM; this technology is useful to realize advanced materials that cannot be obtained conventional manufacturing. 実用化イメージ The EBM technology has received much attention for producing metal parts used in biomedical, aerospace and automotive industries.Rapid prototyping / rapid tooling is one of the applications of this technology. Researchers New Industry Creation Hatchery Center Akihiko Chiba Understanding Biological Control Systems and its Application to Development of Life-Like Resilient Systems       NEXT PREV 特徴・独自性 In contrast to artificial systems, living organisms exhibit astoundingly adaptive and resilient properties. One of the central research goals in our laboratory is to endow artificial systems with similar properties. To this end, we are particularly focusing on the concept of autonomous decentralized control. We have so far successfully developed various types of robots on the basis of decentralized control, including amoeboid robots, snake-like robots, legged robots etc., in collaboration with mathematicians and biologists. 実用化イメージ Development of adaptive autonomous robotic system, Control of Large D.O.F. system Researchers Research Institute of Electrical Communication Akio Ishiguro Development of Novel Scintillator and Piezoelectric Crystals       NEXT PREV 特徴・独自性 Our research target is mainly focused on the topic of development of novel scintillator crystals, piezoelectric crystals, growth technology, characterization and its device application. We design and synthesize new materials from a view point of Crystal Chemistry, and investigate their structure and physical properties. We also study on photo-detector, as suitable photo-detector fully contribute to get maximum signal from scintillator. This activity is very important to realize practical application of our developed materials. Recently, piezoelectric material and high melting temperature alloy project is also started. 実用化イメージ For the purpose of "real" contribution to human culture, we are always carrying out our research activity considering the industrial application. This point is unique feature of our attitude toward science. Researchers Institute for Materials Research Akira Yoshikawa Skeletal Regulation of Energy Metabolism 特徴・独自性 This project studies the influence of bone on energy metabolism in the body through health and disease. 実用化イメージ This project may come up with new tools for metabolic syndrome prediction, therapy and diagnosis . Researchers Frontier Research Institute for Interdisciplinary Sciences Aseel Mahmoud Suleiman Marahleh Methods to Restore Strelity of Gramineous Plants under High- and Low-Temperature Stress Conditions NEXT PREV 特徴・独自性 Plant reproductive development is more sensitive than vegetative growth to many environmental stresses. High-temperature injury is becoming an increasingly serious problem due to recent global warming. In wheat, barley, and other crops, the early phase of anther development is most susceptible to high temperature. Oppositely, grain yields in rice plants are often reduced by exposure to low temperature. Unexpected climate change, such as abnormally hot or cool summer temperatures, have occurred repeatedly during recent years. This method indicates that an appropriate use of specific phytohormones, such as auxin and GA, may promote stress tolerance and adaptation to abiotic stresses. 実用化イメージ These potentially novel functions of the classical phytohormones will be important sustainable agriculture in the face of global climate change. Researchers Graduate School of Life Sciences Atsushi Higashitani X-Ray Phase Imaging for High-Sensitive Non-Destructive Testing NEXT PREV 特徴・独自性 Conventional X-ray imaging methods that rely on X-ray attenuation cannot generate clear contrast in the observation of low-density materials such as polymers consisting of low-Z elements. However, the sensitivity to the materials can be improved drastically by X-ray phase imaging that detects X-ray refraction caused by the materials. X-ray Talbot or Talbot-Lau interferometry consisting of X-ray transmission gratings is now constructed in laboratories for X-ray phase imaging. X-ray phase tomography is also realized, enabling high-sensitive three-dimensional observation. X-ray phase imaging can be utilized for X-ray non-destructive testing of industrial products and baggage that cannot be checked conventionally. 実用化イメージ We aim at appending a phase-contrast mode to micro-CT apparatuses and developing screening apparatuses in production lines. Researchers Institute of Multidisciplinary Research for Advanced Materials Atsushi Momose  C The Construction of a Decentralized Energy Production System Using Small Methane Fermentation Systems That Utilize Exhaust Heat or Hot Springs and a Local Circulation System     NEXT PREV 特徴・独自性 In this project, we reduce the costs of energy production via anaerobic digestion by utilizing exhaust heat from a factory, which resulted in a positive energy balance, although the methane fermentation system tested was on a small scale. Using small-scale methane fermentation with a positive energy balance, the initial investment is small, enabling a company to invest in, and install, such a system. This would decentralize energy production within an area. Moreover, this system not only produces energy, but is a basis for resource recycling. 実用化イメージ Food factory, hotel, restaurant, where food garbage or organic waste was produced much. Researchers Graduate School of Agricultural Science Chika Tada  D Gastroenteritis virus-binding enteric bacteria for probiotics   NEXT PREV 特徴・独自性 We have found enteric bacteria that can capture gastroenteritis viruses, such as norovirus and rotavirus, through histo-blood group antigen (HBGA)-like substances. These HBGA-positive bacteria give a significant impant on the ecology of gastroenteritis viruses in human body and in environments. 実用化イメージ Since gastroenteritis virus-binding bacteria can affect the viral infection capability to host cells, these bacteria and produced HBGA-like substances are available in probiotics application. Researchers Graduate School of Engineering Daisuke Sano  E Development of the next generation anti-HIV agents     NEXT PREV 特徴・独自性 HIV infection is one of most serious concern in infectious diseases. We will perform anti-HIV assays for unmet medical needs in control of HIV infections with established novel assays. We have developed reverse transcriptase inhibitor that has novel mechanism of inhibition, translocation-inhibition (J Biol Chem, 2009). Dr Kodama participated in the primary screening and development of a new HIV integrase inhibitor, elvitegravir (J Virol 2009), and a unique reverse transcriptase inhibitor, islatravir, which phase III clinical trials by the Merck & Co., Inc. will complete, soon. We have a representative resistant HIV strain-library for anti-HIV screening and several target oriented high through-put screening systems. 実用化イメージ We can establish high through-put screening for new targets, so please consult with us individually. We are open to joint development requiring BSL3/P3 experimental facilities and academic guidance including other microorganisms. Researchers International Research Institute of Disaster Science Eiichi Kodama Development and evaluation of various inhibitors and disinfectants for SARS-CoV-2       NEXT PREV 特徴・独自性 Using the infectious SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2), we are evaluating and developing new therapeutic drug candidates as well as evaluating disinfectants. Further analyses such as mechanism of action and resistance may be applicable. Other pathogens, including influenza virus and drug-resistant bacteria, will be examined upon request and discussion. Through joint and collaborative research with domestic and overseas pharmaceutical companies and related companies, we have experience of their clinical application including basic research. 実用化イメージ We support development and evaluation of various inhibitors and disinfectants for variants of SARS-CoV-2 as well as wild type. Researchers International Research Institute of Disaster Science Eiichi Kodama Hydrogen embrittlement of high strength steels       NEXT PREV 特徴・独自性 We are studying hydrogen embrittlement property of high strength steels from the aspects of both the effect of hydrogen on mechanical properties of high strength steels and hydrogen uptake behavior in corrosive environments. The topics of our study includes clarification of mechanism of hydrogen embrittlement of various steels, investigation of hydrogen entry caused by corrosion using electrochemical techniques, hydrogen visualization, proposing evaluation methods for hydrogen embrittlement property and so forth. 実用化イメージ Collaborative research in the field of hydrogen embrittlement, for example, hydrogen embrittlement properties of high strength steels and the effects of metallographic structure and hydrogen traps, proposal of evaluation methods for hydrogen embrittlement property for some specific steel and for parts with specific shape, development of novel hydrogen visualization techniques. Researchers Institute for Materials Research Eiji Akiyama Programming Language Theory and Computation Models       NEXT PREV 特徴・独自性 Our laboratory conducts leading research on programming language theory and high-level computation models. In particular, we focus on research and application of (general proof methods for) program equivalence, functional programing, and type systems (also known as lightweight formal methods), which are attracting revived interests in recent years. Our Japanese translation of "Types and Programming Languages" (Benjamin C. Pierce, University of Pennsylvania)---compiled in cooperation with engineers from top-level electronics and software companies in Japan---has become the 42nd bestseller (rather exceptional as an academic Publications) among new books in Amazon.co.jp. For more information, please see the Web page: http://www.kb.ecei.tohoku.ac.jp/~sumii 実用化イメージ Our technology can be used for design and development of software artifacts, especially programming languages and tools including DSL (domain specific languages), as well as application of functional programming, type systems, or formal methods. Researchers Graduate School of Information Sciences Eijiro Sumii Yeast models of familial Alzheimer disease to screen for gamma-secretase inhibitors and modulators     NEXT PREV 特徴・独自性 Using the yeast transcriptional activator Gal4 system, we reconstituted the production of amyloid beta (Aβ), responsible for Alzheimer disease. Aβ production could be monitored by the positive growth in the selection media or by the reporter enzyme (β-Gal). Utilizing familial Alzheimer disease mutants, we established a system to screen for mutations and chemicals that modulate gamma secretase activity and reduce toxic Aβ42. 実用化イメージ Our yeast system can be used to screen for chemicals, natural products, food ingredients, genes, and mutations that modulate γ-secretase activity and block Aβ42 production specifically. We hope to conduct collaboration research with a willing company for a practical application of this technology in industry. Researchers Graduate School of Agricultural Science Eugene Futai  F Design, fabrication and test of high performance miniaturized sensor and actuator systems       NEXT PREV 特徴・独自性 Micro and nano electro-mechanical systems (MEMS/NEMS) have completely changed human society in the past decades. Many devices that are taken for granted these days like smart phone, future car and drone would be unthinkable without them. The integration of various new kinds of materials, such as metallic glass and nanostructures into micro technologies allows us to create devices with novel performance and characteristics; examples include acoustic sensors and actuators, thermoelectric generators and wafer level packages. In collaboration with partners inside and outside Tohoku University, technologies are being developed that can be transferred to industry ranging from material integration and processes to packaging and reliability. 実用化イメージ Wide collaboration in Microsystem technology is possible. We develop, implement and optimize processes, devices and systems until they are ready for use, keeping in mind reliability, yield and other important features for commercialization. We work with also with partners, such as Fraunhofer. Flexible interlinking of expertise and capacities with other research groups enables us to meet broad project requirements and create complex system solutions. Researchers Micro System Integration Center Froemel Joerg Eckhardt Development of Intelligent Molecules for the Regulation of Gene Expression in Cells       NEXT PREV 特徴・独自性 The artificial control of gene expression by synthetic oligodeoxynucleotides (ODNs) has been the subject of considerable interest. In particular, ODNs conjugated with a cross-linking agent have been expected to enhance the inhibitory effect. Recently, microRNAs (miRNA) endogenously expressed small regulatory non-coding RNAs, are recognized as playing a critical role in regulating gene expression and the great concerns have been raised about efficient antisense oligonucleotides against miRNAs. We have already demonstrated that ODNs bearing a 2-amino-6-vinylpurine (2-AVP) derivative exhibited efficient interstrand cross-linking to cytosine selectively. The unique structural features of AVP are to possess both the hydrogen bond donor-acceptor sites as recognition sites and the vinyl group as a reactive moiety in a single molecule. Recently, we have developed of the novel cross-linking agents, which are designed based on the unique structure of AVP. These derivatives can react to thymine at the complementary site with highly selective and efficient under neutral conditions. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry. 実用化イメージ Researchers Institute of Multidisciplinary Research for Advanced Materials Fumi Nagatsugi Development of Integration of Science and Technology for Tsunami Disaster Mitigation       NEXT PREV 特徴・独自性 The Tsunami Engineering Laboratory (TEL) is the only laboratory in the world that studies tsunamis from an engineering point of view. In addition to studying modern and ancient tsunamis through field surveys and analysis of historical documents, human science, and disaster information, the TEL has developed a numerical simulation of tsunamis. This simulation is currently being used to develop highly accurate quantitative tsunami warnings and design characteristics of waterfront structures. After the 2011 Tohoku earthquake and tsunami, we re-started the research activity to enhance at a new research institute (IRIDeS) and education at a new inter-graduate school doctoral degree program on science for global safety. 実用化イメージ The tsunami prediction technology enables influence, the hazard to the area along the shore in the future and a damage prediction. Where can you cope by current prophylaxis to? I can consider what is short concretely. The technology can be applied to the filed for an administration as well as the social infrastructure, insurance, traffic, and energy relations. Researchers International Research Institute of Disaster Science Fumihiko Imamura Performance enhancement and application development of energy harvesting materials by microstructure design     NEXT PREV 特徴・独自性 To realize IoT society, it is required the sensors, which function without battery charge. We study on energy harvesting materials using our knowledge about materials mechanics and numerical simulation such as finite element method. We recently address to develop energy harvesting devices, which can recovery the unharnessed　energy around us as electrical energy. 実用化イメージ Researchers Graduate School of Environmental Studies Fumio Narita  H Development of Immunobiotic Evaluation System for Functional Feeds as a Livestock Animal Model     NEXT PREV 特徴・独自性 Pattern recognition receptor (PRR) family plays an important role in the defense through recognition of pathogen-associated molecular patterns or microorganisms-associated molecular patterns (PAMPs/MAMPs). Some functional feed materials are thought to regulate intestinal immunity by contact and stimulation of epithelial cells and immunocompetent cells via PRRs in the gastrointestinal tract and induction of cytokine production. In this "new world" of feed immunology, however, much remains unknown about the underlying mechanisms of intestinal immunity because of lack of appropriate intestinal immunoassay system for livestock animals. We have advanced application of originally established porcine and bovine intestinal epitheliocytes (PIE, BIE) cell lines (see photo) for evaluation of immunobiotics and immunogenics exerting anti-inflammatory responses both in PIE cell monolayer and co-culture system with porcine peyer&＃039;s patch immune cells as a peyer&＃039;s patch culture model (see illustration). 実用化イメージ This evaluation system may also contribute to elucidate immunoregulatory mechanism of immunobiotics and immunogenics mediated by pattern recognition receptors essential to future development of not only immunobiotic feeds but also vaccines using immunobiotics to prevent specific diseases. This can benefit mankind by offering immunobiotic feeds as a safer alternative to conventional antibiotic drug therapy. Researchers Graduate School of Agricultural Science Haruki Kitazawa Combustion and Atomization Technology in High-Pressure Gas Turbine Conditions       NEXT PREV 特徴・独自性 Combustion is a complex phenomenon composed of multi-dimensional dynamics of temperature, concentration, velocity, and chemical reactions. Advanced combustion technologies are essential for solving the environmental and energy issues. Our laboratory has a high-pressure combustion test facility which is a unique experimental facility in the world. Research projects have originality, especially in the field of high-pressure combustion and laser diagnostics, and focus on not only aerospace engineering and energy engineering including new fuel technology but also atomization technology and safety operations of chemical plants mostly operated at high pressure. 実用化イメージ Potential collaborations are in the research fields of aerospace propulsions, automobile engines, power generations and chemical plants, in terms of development of gas turbine combustors for various fuels, generation and control of fuel atomizers, laser diagnostics of combustion and safety design of chemical reactors. Researchers Institute of Fluid Science Hideaki Kobayashi Network Roaming System with Flexible Access Control   NEXT PREV 特徴・独自性 The laboratory works on development of authentication wireless LAN systems which refer user attribute to realize flexible access control capability.Improvement and evaluation of new access control is devised based on experience of operation of an international wireless lan roaming service ‘eduroam&＃039; which is based on 802.1x authorization protocol. 実用化イメージ The development contains application of OpenFlow technology to select a connecting network depending on user affiliation, as well as access control based on pre-defined attribute information. Researchers Organization for Innovations in Data Synergy Hideaki Sone 1 2 3 4 5 6 7 8 9 10 ... 13 Browsing History Research Profiles ©TOHOKU UNIVERSITY How to Use FAQ For Researchers Site Policy [jp] ©TOHOKU UNIVERSITY Fields Medical Life Sciences Information Communication Environment Nanotechnology / Materials Energy Manufacturing Technology Social Infrastructure Frontier Liberal Arts Fields Themes Researchers 日本語 ENGLISH Close